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Disambiguation.png This article is about Disease, from 5th edition SRD.
For other uses of Disease, see Disease (disambiguation).
This material from the 5th edition SRD is published under the OGL

A plague ravages the kingdom, setting the adventurers on a quest to find a cure. An adventurer emerges from an ancient tomb, unopened for centuries, and soon finds herself suffering from a wasting illness. A warlock offends some dark power and contracts a strange affliction that spreads whenever he casts spells.

A simple outbreak might amount to little more than a small drain on party resources, curable by a casting of lesser restoration. A more complicated outbreak can form the basis of one or more adventures as characters search for a cure, stop the spread of the disease, and deal with the consequences.

A disease that does more than infect a few party members is primarily a plot device. The rules help describe the effects of the disease and how it can be cured, but the specifics of how a disease works aren’t bound by a common set of rules. Diseases can affect any creature, and a given illness might or might not pass from one race or kind of creature to another. A plague might affect only constructs or undead, or sweep through a halfling neighborhood but leave other races untouched. What matters is the story you want to tell.

List of Diseases[edit]

This section exceeds the text of the SRD

(10 official and unofficial diseases)

DiseaseTargetsIncubationPrimary EffectsSecondary EffectsDamage TypeCarriersSource
Blinding SicknessImmediatepain, reduced Wis checks and savesblindnessSRD5
Bluerot1-4 hoursboils, Con and Cha lossfever, tingling extremities, water breathingnecroticundeadGhosts of Saltmarsh
Cackle FeverHumanoids1-4 hoursfever, aches, exhaustionlaughter, incapacitationpsychicHumanoidsSRD5
Filth FeverImmediatefeverreduced Str checks, saves, and attack rollsSRD5
Flesh RotImmediateflesh decaydecreased Cha checks, vulnerable to damageSRD5
MindfireImmediatefever of the minddecreased Int checks and saves, confusionSRD5
SeizureImmediateshakingdecreased Dex checks, saves, and attack rollsSRD5
Sewer PlagueHumanoids1-4 daysfatigue, cramps, exhaustionrats, vermin, otyughsSRD5
Sight Rotbeast, humanoid1-4 daysreduced visionblindnessSRD5
Slimy DoomImmediatebleedingdecreased Con checks and saves, stunnedSRD5


Back to Main Page5e System Reference Document

Facts about "Disease"
AuthorSRD5 +
Canontrue +
PublicationSRD5 +
TitleDisease +